In an earlier article, we described the mindset and process for implementing and conducting a multi-site study. In this article, we take the perspective of the multi-site study's coordinating centre. Using the Community Mental Health Evaluation Initiative as a case study, we focus on four major aspects of the initiative — data collection and management, the evaluated programs, partnerships, and knowledge transfer. We discuss a variety of challenges that we faced in relation to these activities during the course of our longitudinal multi-site study and how we met them — both those actions that were met with success and those that were not.